De Waterkant is a sub-district of the suburb of Green Point, Cape Town. The neighbourhood is adjacent to the Central Business District on the southeastern end of Somerset Road. From south, it is adjacent to the historically coloured district of Bo-Kaap.

De Waterkant is typically a sought-after address for young professionals, the upper-class gay and lesbian community, and niche restaurants and retailers. The area is home to the Cape Quarter shopping mall and Vega’s Cape Town campus.